Diagnostic Summary

Study staff, following completion and review of the SCID and ACDS or KSADS, completes the diagnostic summary.

Note: Item level data for the follow assessments are not released.

Adult ADHD Clinical Diagnostic Scale (ACDS) V 1.2:

This is a semi-structured interview that establishes both current adult symptomatology and the presence of any ADHD symptoms in childhood. The 18 items in the ACDS match the 18 symptom domains of ADHD noted in DSM-IV. As the SCID does not cover ADHD it is used in conjunction in order to help make or rule out this diagnosis.

Note: This semi-structured interview is administered to all adult participants ages 18-85 years old.

References: Kessler, R. C., Green, J. G., Adler, L. A., Barkley, R. A., Chatterji, S., Faraone, S. V., . . . Van Brunt, D. L. (2010). Structure and diagnosis of adult attention-deficit/hyperactivity disorder: Analysis of expanded symptom criteria from the adult ADHD clinical diagnostic scale. Archives of General Psychiatry, 67(11), 1168-78.

Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS):

The K-SADS is a semi-structured interview designed to assess current and past episodes of psychopathology in children and adolescents, according to DSM-IV criteria. Probes and objective criteria are provided to rate individual symptoms.

Note: This semi-structured interview is administered to all child participants ages 6-17 years old. The interview is first completed with the guardian of the child and is then completed with the child in order to determine past and current diagnoses.

References: Kaufman, J., et al. (1997). Schedule for affective disorders and schizophrenia for school-age children-resent and lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36(7), 980-988).

Structured Clinical Interview for DSM-IV-TR Axis I Disorders – Non-Patient Edition (SCID-I/NP):

A diagnostic semi-structured interview designed to assess current and past episodes of psychopathology in adults, according to DSM-IV criteria. Probes and objective criteria are provided to rate individual symptoms.

Note: This semi-structured interview is administered to all adult participants ages 18-85 years old.

References: First, M., B., Spitzer, R. L., Gibbon, M., and Williams, J.B.W.: Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-patient edition (SCID-I/NP, 1/2010 revision). New York: Biometrics Research, New York State Psychiatric Institute, November 2002.

Medical History Questionnaire-Adult

This questionnaire is designed to get a detailed and comprehensive history of the participant’s medical and psychiatric history. Participants respond Yes or No to a list of possible medical issues, and for some are asked to specify type.

Note: This assessment is given to all adult participants, ages 18-85 years old.

References: Merikangas, K., project in development.

Medical History Questionnaire-Child

This questionnaire is designed to get a detailed and comprehensive history of the participant’s medical and psychiatric history. Parents are asked to respond Yes or No to a list of possible medical issues about their child, and for some are asked to specify type.

Note: This assessment is completed by guardians of child participants, ages 6-17 years old.

References: Merikangas, K., project in development.

Yale Global Tic Severity Scale (YGTSS) (1989)

The YGTSS rating scale is a 10-item semi-structured clinician-rating instrument that provides an evaluation of the number, frequency, intensity, complexity, and interference of motor and phonic symptoms. The items pertaining to the tic ratings are scored on two subscales: motor tics and phonic tics. Behaviors are rated on a 6-point scale. The scale asks individuals to respond based on symptoms experiences only in the past week.

Note: This assessment is administered to all participants, ages 6-85.

References: Leckman J.F., Riddle M.A., Hardin M.T., Ort S.L., Swartz K.L., Stevenson J., et al. The Yale Global Tic Severity Scale: Initial testing of a clinician-rated scale of tic severity. Journal of the American Academy of Child and Adolescent Psychiatry. 1989;28:566–573.